In Vitro and In Vivo Evaluation of 3D Printed Capsules with Pressure Triggered Release Mechanism for Oral Peptide Delivery

In this study a 3D printed capsule designed to break from the physiological pressures in antropyloric region was evaluated for its ability deliver synthetic octapeptide octreotide beagle dogs when co-formulated with permeation enhancer sodium caprate. The pressure sensitive capsules were compared traditional enteric coated hard gelatin and tablets. Paracetamol, which is completely absorbed dogs, included formulations used as an absorption marker give information about vivo performance of dosage forms. released drug 50% dogs. cases where released, there no difference bioavailability or Cmax When comparing all forms, correlation seen between paracetamol bioavailability, suggesting that high release rate may be beneficial peptide delivered together